(hydroxymethylglutaryl-CoA reductase (NADPH))-phosphatase

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In enzymology, a [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase (EC 3.1.3.47) is an enzyme that catalyzes the chemical reaction

[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H₂O $\rightleftharpoons$ [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate

Thus, the two substrates of this enzyme are [[[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate]] and H₂O, whereas its two products are [[[hydroxymethylglutaryl-CoA reductase (NADPH)]]] and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate phosphohydrolase. This enzyme is also called reductase phosphatase.

[edit] References

IUBMB entry for 3.1.3.47
BRENDA references for 3.1.3.47 (Recommended.)
PubMed references for 3.1.3.47
PubMed Central references for 3.1.3.47
Google Scholar references for 3.1.3.47
Gil G, Hegardt FG (1982). "Some properties of purified 3-hydroxy-3-methylglutaryl coenzyme A reductase phosphatases from rat liver". Arch. Biochem. Biophys. 214: 192–8. PMID 6282220.
Gil G, Sitges M, Hegardt FG (1981). "Purification and properties of rat liver hydroxymethylglutaryl coenzyme A reductase phosphatases". Biochim. Biophys. Acta. 663: 211–21. PMID 6260210.