(heparan sulfate)-glucosamine 3-sulfotransferase 3

From Wikipedia, the free encyclopedia

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 3 (EC 2.8.2.30) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine $\rightleftharpoons$ adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and [[[heparan sulfate]-glucosamine]], whereas its two products are adenosine 3',5'-bisphosphate and [[[heparan sulfate]-glucosamine 3-sulfate]].

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase. This enzyme participates in heparan sulfate biosynthesis and glycan structures - biosynthesis 1.

[edit] References

IUBMB entry for 2.8.2.30
BRENDA references for 2.8.2.30 (Recommended.)
PubMed references for 2.8.2.30
PubMed Central references for 2.8.2.30
Google Scholar references for 2.8.2.30
RD (1999). "Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues". J. Biol. Chem. 274: 38155–62. PMID 10608887.
Eisenberg RJ, Rosenberg RD, Spear PG (1999). "A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry". Cell. 99: 13–22. PMID 10520990.
Jenkins NA, Rosenberg RD (1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J. Biol. Chem. 274: 5170–84. PMID 9988767.
Rosenberg RD (1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities". J. Biol. Chem. 274: 5185–92. PMID 9988768.