(heparan sulfate)-glucosamine 3-sulfotransferase 2

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In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 2 (EC 2.8.2.29) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine $\rightleftharpoons$ adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and [[[heparan sulfate]-glucosamine]], whereas its two products are adenosine 3',5'-bisphosphate and [[[heparan sulfate]-glucosamine 3-sulfate]].

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase. Other names in common use include glucosaminyl 3-O-sulfotransferase, heparan sulfate D-glucosaminyl 3-O-sulfotransferase, and isoform/isozyme 2 (3-OST-2, HS3ST2). This enzyme participates in heparan sulfate biosynthesis and glycan structures - biosynthesis 1.

[edit] References

IUBMB entry for 2.8.2.29
BRENDA references for 2.8.2.29 (Recommended.)
PubMed references for 2.8.2.29
PubMed Central references for 2.8.2.29
Google Scholar references for 2.8.2.29
Jenkins NA, Rosenberg RD (1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J. Biol. Chem. 274: 5170–84. PMID 9988767.
Rosenberg RD (1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities". J. Biol. Chem. 274: 5185–92. PMID 9988768.