(cytochrome c)-lysine N-methyltransferase

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In enzymology, a [cytochrome c]-lysine N-methyltransferase (EC 2.1.1.59) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + [cytochrome c]-L-lysine $\rightleftharpoons$ S-adenosyl-L-homocysteine + [cytochrome c]-N₆-methyl-L-lysine

Thus, the two substrates of this enzyme are S-adenosyl methionine and [[[cytochrome c]-L-lysine]], whereas its two products are S-adenosylhomocysteine and [[[cytochrome c]-N6-methyl-L-lysine]].

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:[cytochrome c]-L-lysine N6-methyltransferase. Other names in common use include cytochrome c (lysine) methyltransferase, cytochrome c methyltransferase, cytochrome c-specific protein methylase III, cytochrome c-specific protein-lysine methyltransferase, S-adenosyl-L-methionine:[cytochrome c]-L-lysine, and 6-N-methyltransferase. This enzyme participates in lysine degradation.

[edit] References

IUBMB entry for 2.1.1.59
BRENDA references for 2.1.1.59 (Recommended.)
PubMed references for 2.1.1.59
PubMed Central references for 2.1.1.59
Google Scholar references for 2.1.1.59
Durban E, Nochumson S, Kim S, Paik WK, Chan SK (1978). "Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa. Purification, characterization, and substrate requirements". J. Biol. Chem. 253: 1427–35. PMID 203592.
Nochumson S, Durban E, Kim S, Paik WK (1977). "Cytochrome c-specific protein methylase III from Neurospora crassa". Biochem. J. 165: 11–8. PMID 196592.
Valentine J, Pettigrew GW (1982). "A cytochrome c methyltransferase from Crithidia oncopelti". Biochem. J. 201: 329–38. PMID 6282265.