(2,3-dihydroxybenzoyl)adenylate synthase

From Wikipedia, the free encyclopedia

In enzymology, a (2,3-dihydroxybenzoyl)adenylate synthase (EC 2.7.7.58) is an enzyme that catalyzes the chemical reaction

ATP + 2,3-dihydroxybenzoate diphosphate + (2,3-dihydroxybenzoyl)adenylate

Thus, the two substrates of this enzyme are ATP and 2,3-dihydroxybenzoate, whereas its two products are diphosphate and (2,3-dihydroxybenzoyl)adenylate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:2,3-dihydroxybenzoate adenylyltransferase. This enzyme is also called 2,3-dihydroxybenzoate-AMP ligase. This enzyme participates in biosynthesis of siderophore group nonribosomal and [[]].

[edit] References

• IUBMB entry for 2.7.7.58
• BRENDA references for 2.7.7.58 (Recommended.)
• PubMed references for 2.7.7.58
• PubMed Central references for 2.7.7.58
• Google Scholar references for 2.7.7.58
• Rusnak F, Faraci WS, Walsh CT (1989). "Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product". Biochemistry. 28: 6827–35. doi:10.1021/bi00443a008. PMID 2531000. 

[edit] External links

The CAS registry number for this enzyme class is 122332-73-4.

• IUBMB entry for 2.7.7.58

• KEGG entry for 2.7.7.58

• BRENDA entry for 2.7.7.58

• NiceZyme view of 2.7.7.58

• EC2PDB: PDB structures for 2.7.7.58

• PRIAM entry for 2.7.7.58

• PUMA2 entry for 2.7.7.58

• IntEnz: Integrated Enzyme entry for 2.7.7.58

• MetaCyc entry for 2.7.7.58

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008668: (2,3-dihydroxybenzoyl)adenylate synthase

• AMIGO entry for GO code 0008668: (2,3-dihydroxybenzoyl)adenylate synthase