(-)-endo-fenchol synthase

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In enzymology, a (-)-endo-fenchol synthase (EC 4.2.3.10) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate + H₂O $\rightleftharpoons$ (-)-endo-fenchol + diphosphate

Thus, the two substrates of this enzyme are geranyl diphosphate and H₂O, whereas its two products are (-)-endo-fenchol and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]. Other names in common use include (-)-endo-fenchol cyclase, and geranyl pyrophosphate:(-)-endo-fenchol cyclase. This enzyme participates in monoterpenoid biosynthesis.

[edit] References

IUBMB entry for 4.2.3.10
BRENDA references for 4.2.3.10 (Recommended.)
PubMed references for 4.2.3.10
PubMed Central references for 4.2.3.10
Google Scholar references for 4.2.3.10
Croteau R, Miyazaki JH, Wheeler CJ (1989). "Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(-)-endo-fenchol cyclase from fennel (Foeniculum vulgare)". Arch. Biochem. Biophys. 269: 507–16. doi:10.1016/0003-9861(89)90134-3. PMID 2919880.
Croteau R, Satterwhite DM, Wheeler CJ, Felton NM (1988). "Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (-)-endo-fenchol". J. Biol. Chem. 263: 15449–53. PMID 3170591.