N-acylneuraminate cytidylyltransferase

From Wikipedia, the free encyclopedia

This article or section needs to be wikified to meet Wikipedia's quality standards. Please help improve this article with relevant internal links. (January 2008)

In enzymology, a N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) is an enzyme that catalyzes the chemical reaction

CTP + N-acylneuraminate diphosphate + CMP-N-acylneuraminate

Thus, the two substrates of this enzyme are CTP and N-acylneuraminate, whereas its two products are diphosphate and CMP-N-acylneuraminate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:N-acylneuraminate cytidylyltransferase. Other names in common use include CMP-sialate pyrophosphorylase, CMP-sialate synthase, cytidine 5'-monophosphosialic acid synthetase, CMP-Neu5Ac synthetase, CMP-NeuAc synthetase, acylneuraminate cytidyltransferase, CMP-N-acetylneuraminate synthetase, CMP-N-acetylneuraminate synthase, CMP-N-acetylneuraminic acid synthase, CMP-NANA synthetase, CMP-sialate synthetase, CMP-sialic synthetase, cytidine 5'-monophospho-N-acetylneuraminic acid synthetase, cytidine 5-monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphosialic acid synthetase, cytidine monophosphoacetylneuraminic synthetase, cytidine monophosphosialate pyrophosphorylase, cytidine monophosphosialate synthetase, and acetylneuraminate cytidylyltransferase. This enzyme participates in aminosugars metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1EYR, 1EZI, and 1QWJ.

[edit] References

• IUBMB entry for 2.7.7.43
• BRENDA references for 2.7.7.43 (Recommended.)
• PubMed references for 2.7.7.43
• PubMed Central references for 2.7.7.43
• Google Scholar references for 2.7.7.43
• Kean EL, Roseman S (1966). "The sialic acids. X. Purification and properties of cytidine 5'-monophosphosialic acid synthetase". J. Biol. Chem. 241: 5643–50. PMID 4288894. 

[edit] External links

The CAS registry number for this enzyme class is 9067-82-7.

• IUBMB entry for 2.7.7.43

• KEGG entry for 2.7.7.43

• BRENDA entry for 2.7.7.43

• NiceZyme view of 2.7.7.43

• EC2PDB: PDB structures for 2.7.7.43

• PRIAM entry for 2.7.7.43

• PUMA2 entry for 2.7.7.43

• IntEnz: Integrated Enzyme entry for 2.7.7.43

• MetaCyc entry for 2.7.7.43

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008781: N-acylneuraminate cytidylyltransferase

• AMIGO entry for GO code 0008781: N-acylneuraminate cytidylyltransferase