Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase

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In enzymology, an alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.99.3) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein $\rightleftharpoons$ CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein, whereas its 3 products are CMP, glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-, and glycoprotein.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl )-glycoprotein alpha-2,6-N-acetylneuraminyltransferase. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1.

[edit] References

IUBMB entry for 2.4.99.3
BRENDA references for 2.4.99.3 (Recommended.)
PubMed references for 2.4.99.3
PubMed Central references for 2.4.99.3
Google Scholar references for 2.4.99.3
Sadler JE, Rearick JI, Hill RL (1979). "Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands". J. Biol. Chem. 254: 5934–41. PMID 447688.